Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.54 |
| ▸ | JAK2 | O60674 | 14/20 | 0.54 |
| ▸ | JAK1 | P23458 | 9/20 | 0.53 |
| ▸ | TYK2 | P29597 | 6/20 | 0.48 |
| ▸ | BTK | Q06187 | 7/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635685 | 0.85 | BTK (0.60) | JAK3JAK2BTKEGFRLCK | |
| SCHEMBL19635666 | 0.85 | JAK3 (0.72) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL19635682 | 0.80 | LCK (0.64) | JAK3JAK2BTKEGFRLCK | |
| SCHEMBL19635197 | 0.80 | BTK (0.67) | BTKEGFRLCKLYN | |
| SCHEMBL28370698 | 0.80 | BTK (0.67) | BTKEGFRLCKLYN | |
| SCHEMBL19635199 | 0.80 | BTK (0.67) | BTKEGFRLCKLYN | |
| SCHEMBL19635228 | 0.78 | IGF1R (0.47) | JAK3JAK2JAK1BTKEGFR | |
| SCHEMBL130641 | 0.77 | PIK3CD (0.60) | JAK3EGFR | |
| SCHEMBL28370688 | 0.76 | BTK (0.56) | BTKEGFRLCKLYN | |
| SCHEMBL19635195 | 0.76 | BTK (0.56) | BTKEGFRLCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111153906-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-111153906-A | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-107383013-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-03-31 | — | — | CN | disclosed |
| WO-2017198049-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | 浙江予川医药科技有限公司 | 2017-11-23 | — | — | WO | disclosed |