Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 6/20 | 0.64 |
| ▸ | SRC | P12931 | 3/20 | 0.64 |
| ▸ | TEK | Q02763 | 3/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | BTK | Q06187 | 11/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.49 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.49 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635199 | 0.88 | BTK (0.67) | LCKSRCTEKKDRBTK | |
| SCHEMBL19635197 | 0.88 | BTK (0.67) | LCKSRCTEKKDRBTK | |
| SCHEMBL19635685 | 0.88 | BTK (0.60) | LCKSRCTEKKDRBTK | |
| SCHEMBL28370698 | 0.88 | BTK (0.67) | LCKSRCTEKKDRBTK | |
| SCHEMBL19635195 | 0.82 | BTK (0.56) | LCKSRCTEKKDRBTK | |
| SCHEMBL19635196 | 0.82 | BTK (0.56) | LCKSRCTEKKDRBTK | |
| SCHEMBL28370688 | 0.82 | BTK (0.56) | LCKSRCTEKKDRBTK | |
| SCHEMBL19635681 | 0.80 | JAK3 (0.54) | LCKBTKLYNEGFRJAK2 | |
| SCHEMBL19635228 | 0.79 | IGF1R (0.47) | LCKBTKEGFRERBB2IGF1R | |
| SCHEMBL5786266 | 0.78 | SRC (1.00) | LCKSRCTEKKDRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111153906-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-111153906-A | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-107383013-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-03-31 | — | — | CN | disclosed |
| WO-2017198049-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | 浙江予川医药科技有限公司 | 2017-11-23 | — | — | WO | disclosed |