Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.58 |
| ▸ | BLK | P51451 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | ITK | Q08881 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635810 | 1.00 | BTK (0.58) | BTKBLKEGFRLCKITK | |
| SCHEMBL19635643 | 1.00 | BTK (0.58) | BTKBLKEGFRLCKITK | |
| SCHEMBL19635188 | 0.90 | BTK (0.69) | BTKBLKEGFRLCKITK | |
| SCHEMBL19635194 | 0.90 | BTK (0.69) | BTKBLKEGFRLCKITK | |
| SCHEMBL19636022 | 0.87 | BTK (0.75) | BTKBLKEGFRLCKITK | |
| SCHEMBL19635809 | 0.87 | BTK (0.75) | BTKBLKEGFRLCKITK | |
| SCHEMBL19635646 | 0.86 | BTK (0.58) | BTKBLKEGFRLCKITK | |
| SCHEMBL19635642 | 0.86 | BTK (0.58) | BTKBLKEGFRLCKITK | |
| SCHEMBL19635644 | 0.86 | BTK (0.58) | BTKBLKEGFRLCKITK | |
| SCHEMBL19635202 | 0.85 | BTK (0.64) | BTKBLKEGFRLCKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111153906-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-111153906-A | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-107383013-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-03-31 | — | — | CN | disclosed |
| WO-2017198049-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | 浙江予川医药科技有限公司 | 2017-11-23 | — | — | WO | disclosed |