Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 6/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 7/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | PTGFR | P43088 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196044 | 0.85 | PTGER4 (0.51) | PTGER4PTGER2PTGDRTBXA2RPTGER1 | |
| SCHEMBL196767 | 0.85 | PTGER4 (0.43) | PTGER4PTGER2PDE2APTGDRTBXA2R | |
| SCHEMBL22633322 | 0.81 | CCR9 (0.43) | VNN1 | |
| SCHEMBL247942 | 0.78 | PTGER4 (0.55) | PTGER4PTGER2PTGDRTBXA2RPTGER1 | |
| SCHEMBL1952872 | 0.74 | PTGER4 (0.52) | PTGER4PTGER2PDE2APTGDRTBXA2R | |
| SCHEMBL253776 | 0.74 | PTGER4 (0.54) | PTGER4PTGER2PTGDRTBXA2RPTGER1 | |
| SCHEMBL197059 | 0.67 | PTGER4 (0.52) | PTGER4PTGER2PDE2APTGDRTBXA2R | |
| SCHEMBL28113612 | 0.67 | PDE2A (0.58) | PTGER4PTGER2PDE2APTGDRTBXA2R | |
| SCHEMBL3223346 | 0.65 | SRD5A2 (0.44) | — | |
| SCHEMBL197366 | 0.64 | PTGER4 (0.49) | PTGER4PTGER2PDE2APTGDRTBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500211-A | — | — | 2012-01-05 | — | — | JP | claimed |
| US-20110136887-A1 | Heterocyclic Amide Derivatives as EP4 Receptor Antagonists | BETA PHARMA CANADA INC. (CA) | 2011-06-09 | — | — | US | claimed |
| EP-2320906-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Beta Pharma Canada Inc. (CA) | 2011-05-18 | — | — | EP | claimed |
| WO-2010019796-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | CHEMIETEK, LLC (US) | 2010-02-18 | — | — | WO | claimed |
| US-12240860-B2 | Heterobicyclic carboxylic acids and salts thereof | Foshan Ionova Biotherapeutics Co., Inc. (CN) | 2025-03-04 | — | — | US | disclosed |
| CN-111936502-B | Heterobicyclic carboxylic acids and salts thereof | 深圳市原力生命科学有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117643587-A | Heterobicyclic carboxylic acids for the treatment of cancer | 深圳市原力生命科学有限公司 | 2024-03-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12240860-B2 | Heterobicyclic carboxylic acids and salts thereof | PTGER4, PTGER1, GPR4 | PTGER4 1/4885PTGER2 9/4885PDE2A 4418/4885 |
| US-20110136887-A1 | Heterocyclic Amide Derivatives as EP4 Receptor Antagonists | PTGER4, PTGER1, PTGER2 | PTGER4 1/4885PTGER2 3/4885PDE2A 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.