Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25021649 | 0.88 | PDE10A (0.30) | — | |
| SCHEMBL19637369 | 0.80 | HTT (0.35) | HTT | |
| SCHEMBL19637079 | 0.75 | HTT (0.32) | HTTMAPTHPGDTSHR | |
| SCHEMBL19637432 | 0.72 | KDM4E (0.36) | — | |
| SCHEMBL22994841 | 0.71 | KDM4E (0.38) | — | |
| SCHEMBL22994752 | 0.69 | KDM4E (0.35) | MAPTHPGD | |
| SCHEMBL21912065 | 0.68 | KDM4E (0.34) | MAPTHPGD | |
| SCHEMBL19637172 | 0.67 | HTT (0.32) | HTT | |
| SCHEMBL19636917 | 0.67 | HRH3 (0.42) | — | |
| SCHEMBL19637446 | 0.67 | KDM4E (0.36) | MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458445-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2020055760-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |