Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19637165 | 0.88 | HRH3 (0.45) | HRH3KCNH2SIGMAR1ALDH1A1 | |
| SCHEMBL19637369 | 0.74 | HTT (0.35) | — | |
| SCHEMBL21846218 | 0.72 | HRH3 (0.35) | HRH3 | |
| SCHEMBL21895605 | 0.71 | KRAS (0.43) | HRH3KCNH2HRH4 | |
| SCHEMBL25997033 | 0.68 | L3MBTL1 (0.54) | HRH3KCNH2HRH1HRH4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7901429 | 0.63 | KCNH2 (0.63) | KCNH2 | |
| SCHEMBL4465342 | 0.62 | HRH3 (0.50) | HRH3KCNH2HRH1HRH4 | |
| SCHEMBL1875861 | 0.62 | HRH3 (0.56) | HRH3KCNH2HRH1HRH4ALDH1A1 | |
| SCHEMBL23804894 | 0.61 | HRH3 (0.77) | HRH3KCNH2SIGMAR1HRH1ALDH1A1 | |
| SCHEMBL491935 | 0.61 | HRH3 (0.88) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710439-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-02-15 | — | — | EP | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |