Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19637079 | 0.84 | HTT (0.32) | HTTCYP1A2 | |
| SCHEMBL21912065 | 0.82 | KDM4E (0.34) | MEN1KMT2A | |
| SCHEMBL19637432 | 0.81 | KDM4E (0.36) | — | |
| SCHEMBL19637255 | 0.80 | HTT (0.34) | HTT | |
| SCHEMBL22994841 | 0.79 | KDM4E (0.38) | MEN1CYP1A2KMT2A | |
| SCHEMBL19636917 | 0.74 | HRH3 (0.42) | — | |
| SCHEMBL22086716 | 0.74 | CHRNB2 (0.44) | — | |
| SCHEMBL19637446 | 0.72 | KDM4E (0.36) | MEN1KMT2A | |
| SCHEMBL19637394 | 0.71 | ABCB11 (0.32) | CYP1A2 | |
| SCHEMBL22994768 | 0.70 | KDM4E (0.32) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710439-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-02-15 | — | — | EP | disclosed |
| EP-3458445-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2020055760-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |