Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 5/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19616741 | 0.89 | C5AR1 (0.47) | TLR9TLR7ACHEBRS3CKS1B | |
| SCHEMBL21458581 | 0.89 | ACHE (0.40) | TLR9TLR7ACHEP2RX7BRS3 | |
| SCHEMBL21458579 | 0.89 | ACHE (0.40) | TLR9TLR7ACHEP2RX7BRS3 | |
| SCHEMBL25021056 | 0.87 | GPR119 (0.40) | TLR9TLR7ACHEP2RX7C5AR1 | |
| SCHEMBL19948053 | 0.87 | BRS3 (0.43) | TLR9TLR7ACHEBRS3CKS1B | |
| SCHEMBL19947629 | 0.87 | ACHE (0.44) | TLR9TLR7ACHEBRS3CKS1B | |
| SCHEMBL29428691 | 0.85 | JAK1 (0.39) | ACHEBRS3C5AR1 | |
| SCHEMBL26752557 | 0.85 | JAK1 (0.39) | ACHEBRS3C5AR1 | |
| SCHEMBL19616714 | 0.85 | MTOR (0.43) | TLR9TLR7ACHEBRS3CKS1B | |
| SCHEMBL29697506 | 0.84 | KIT (0.50) | TLR9TLR7ACHEBRS3CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710439-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-02-15 | — | — | EP | disclosed |
| EP-3458445-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |