Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA2 | Q9HCG7 | 14/20 | 0.43 |
| ▸ | GBA1 | P04062 | 8/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8518882 | 0.88 | GNAO1 (0.46) | GBA2GBA1GNAO1 | |
| SCHEMBL9368277 | 0.86 | GNAO1 (0.53) | GBA1GNAO1 | |
| Hydrochloric Acid SCHEMBL29518770 | 0.83 | GNAO1 (0.58) | GBA1GNAO1 | |
| SCHEMBL18666794 | 0.81 | HRH3 (0.43) | HRH3GNAO1 | |
| SCHEMBL13560174 | 0.81 | GBA1 (0.43) | GBA1GNAO1 | |
| SCHEMBL1999164 | 0.80 | GBA1 (0.47) | GBA1HRH3 | |
| SCHEMBL2433913 | 0.78 | BCHE (0.49) | GBA1 | |
| SCHEMBL2433914 | 0.78 | BCHE (0.49) | GBA1 | |
| SCHEMBL15040841 | 0.78 | HRH3 (0.48) | HRH3 | |
| SCHEMBL1919292 | 0.77 | GNAO1 (0.53) | GBA2GBA1HRH3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |