Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | CASP2 | P42575 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31225326 | 1.00 | ALDH1A1 (0.57) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL15055285 | 1.00 | ALDH1A1 (0.57) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL21606691 | 0.85 | KDM4E (0.50) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL16216733 | 0.83 | MEN1 (0.46) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL27210040 | 0.83 | MEN1 (0.46) | ALDH1A1LMNAMEN1KMT2ARAB9A | |
| SCHEMBL21606690 | 0.82 | KDM4E (0.47) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL21606860 | 0.82 | KDM4E (0.47) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL24742647 | 0.82 | KDM4E (0.44) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL19638852 | 0.82 | ALDH1A1 (0.79) | ALDH1A1LMNAMEN1KMT2ARAB9A | |
| SCHEMBL15055320 | 0.82 | ALDH1A1 (0.79) | ALDH1A1LMNAMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2793884-B1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) | 2017-11-29 | — | — | EP | claimed |