SCHEMBL15055320

SCHEMBL15055320

Nc1ccc(Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)cc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.79
LMNA P02545 4/20 0.79
MEN1 O00255 4/20 0.55
KMT2A Q03164 4/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
RAB9A P51151 1/20 0.53
TDP1 Q9NUW8 2/20 0.50
CYP3A4 P08684 1/20 0.50
TSHR P16473 1/20 0.50
PGR P06401 1/20 0.50
MAOA P21397 2/20 0.44
EPHX2 P34913 1/20 0.44
GAA P10253 3/20 0.43
POLB P06746 2/20 0.43
GFER P55789 2/20 0.43
MAPT P10636 4/20 0.43
TEAD4 Q15561 1/20 0.42
MAOB P27338 1/20 0.42
NPC1 O15118 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19638852 1.00 ALDH1A1 (0.79) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL27845478 0.91 LMNA (0.61) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL2710493 0.90 ALDH1A1 (0.64) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL399431 0.89 ALDH1A1 (1.00) ALDH1A1LMNAMEN1KMT2AL3MBTL1
Hydrochloric Acid SCHEMBL1983434 0.87 LMNA (0.96) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL2708118 0.83 ALDH1A1 (0.58) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL2706770 0.83 ALDH1A1 (0.54) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL16216731 0.82 LMNA (0.52) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL21752967 0.82 LMNA (0.52) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL19638786 0.82 ALDH1A1 (0.57) ALDH1A1LMNAMEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190219566-A1 METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2019-07-18 US claimed
EP-3332783-A1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS Ecole Polytechnique Fédérale de Lausanne (EPFL) (CH) 2018-06-13 EP claimed
EP-2793884-B1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) 2017-11-29 EP claimed
US-9296682-B2 Inhibitors of notch signalling pathway and use thereof in treatment of cancers ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2016-03-29 US claimed
EP-2793884-A1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS Ecole Polytechnique Federale de Lausanne (EPFL) (CH) 2014-10-29 EP claimed
WO-2013093885-A1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS Ecole polytechnique fédérale de Lausanne (EPFL) (CH) 2013-06-27 WO claimed
EP-3332783-B1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) 2024-12-04 EP disclosed
CN-119019324-A Process for preparing aminodiaryl ethers and aminodiaryl ether hydrochlorides 塞莱斯蒂亚生物技术股份公司 2024-11-26 CN disclosed
US-12030855-B2 Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts CELLESTIA BIOTECH AG (CH) 2024-07-09 US disclosed
US-20210382038-A1 METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2021-12-09 US disclosed
US-20210382038-A1 METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2021-12-09 US disclosed
US-11085918-B2 Method for identifying modulators of notch signaling ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2021-08-10 US disclosed
US-11085918-B2 Method for identifying modulators of notch signaling ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2021-08-10 US disclosed
WO-2015051149-A1 SORAFENIB ANALOGS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2015-04-09 WO disclosed
US-20140329867-A1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 2014-11-06 US disclosed
US-20140329867-A1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 2014-11-06 US disclosed
US-20140329867-A1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 2014-11-06 US disclosed
EP-2793884-A1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS Ecole Polytechnique Federale de Lausanne (EPFL) (CH) 2014-10-29 EP disclosed
WO-2013093885-A1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS Ecole polytechnique fédérale de Lausanne (EPFL) (CH) 2013-06-27 WO disclosed
WO-2013093885-A1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS Ecole polytechnique fédérale de Lausanne (EPFL) (CH) 2013-06-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210382038-A1 METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING NOTCH3, NOTCH1, NOTCH4 ALDH1A1 3224/4885LMNA 2374/4885MEN1 469/4885
US-20190219566-A1 METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING NOTCH3, NOTCH1, NOTCH4 ALDH1A1 3224/4885LMNA 2374/4885MEN1 469/4885
US-11085918-B2 Method for identifying modulators of notch signaling NOTCH3, NOTCH1, NOTCH4 ALDH1A1 3224/4885LMNA 2374/4885MEN1 469/4885
US-20140329867-A1 INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS NOTCH3, NOTCH1, NOTCH4 ALDH1A1 2582/4885LMNA 2863/4885MEN1 445/4885
US-12030855-B2 Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts ADH1C, ADH1A, DDC ALDH1A1 42/4885LMNA 3004/4885MEN1 166/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.