Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.44 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.44 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.44 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | MECP2 | P51608 | 1/20 | 0.44 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743332 | 0.95 | CYP19A1 (0.50) | CYP19A1NPY5RMAPTNFKB1NFKB2 | |
| SCHEMBL27913336 | 0.80 | LOXL2 (0.64) | MAPTKMT2ASMN1; SMN2MEN1NPC1 | |
| Dipyridyl SCHEMBL28135789 | 0.77 | KDM4E (0.64) | CYP19A1SMN1; SMN2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL203773 | 0.76 | CYP19A1 (0.60) | CYP19A1MAPTNFKB1NFKB2KMT2A | |
| SCHEMBL12433044 | 0.76 | CYP19A1 (0.51) | CYP19A1NPY5RMAPTNFKB1NFKB2 | |
| SCHEMBL1205231 | 0.75 | PDE10A (0.55) | CYP19A1MAPTSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL12351811 | 0.75 | LOXL2 (0.66) | MAPTKMT2ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL206699 | 0.75 | MAPT (0.63) | NPY5RMAPTNFKB1NFKB2KMT2A | |
| SCHEMBL206259 | 0.75 | MAPT (0.63) | NPY5RMAPTNFKB1NFKB2KMT2A | |
| SCHEMBL7221537 | 0.75 | ECE1 (0.43) | TDP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3581572-B1 | ADENOSINE A3 RECEPTOR MODULATORS | PALOBIOFARMA SL (ES) | 2020-11-25 | — | — | EP | disclosed |
| US-10744125-B2 | Adenosine A3 receptor modulators | PALOBIOFARMA, S.L. (ES) | 2020-08-18 | — | — | US | disclosed |
| EP-3248964-B1 | THIAZOLE MODULATORS OF A3 ADENOSINE RECEPTORS | PALOBIOFARMA SL (ES) | 2019-07-17 | — | — | EP | disclosed |
| US-10238637-B2 | Modulators of the adenosine A3 receptors | PALOBIOFARMA, S.L. (ES) | 2019-03-26 | — | — | US | disclosed |
| US-20180263963-A1 | MODULATORS OF THE ADENOSINE A3 RECEPTORS | PALOBIOFARMA, S.L. (ES) | 2018-09-20 | — | — | US | disclosed |
| EP-3248964-A1 | THIAZOLE MODULATORS OF A3 ADENOSINE RECEPTORS | PALOBIOFARMA S.L. (ES) | 2017-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180263963-A1 | MODULATORS OF THE ADENOSINE A3 RECEPTORS | ADORA3, ADORA2A, ADORA1 | CYP19A1 1389/4885NPY5R 1351/4885MAPT 3832/4885 |
| US-10744125-B2 | Adenosine A3 receptor modulators | ADORA3, ADORA2A, ADORA1 | CYP19A1 789/4885NPY5R 1173/4885MAPT 4548/4885 |
| US-10238637-B2 | Modulators of the adenosine A3 receptors | ADORA3, ADORA2A, ADORA1 | CYP19A1 1389/4885NPY5R 1351/4885MAPT 3832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.