Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.56 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30195485 | 1.00 | ALDH1A1 (0.58) | ALDH1A1FUCA1SLC18A3ACHEBCHE | |
| SCHEMBL5157969 | 0.85 | FUCA1 (0.66) | ALDH1A1FUCA1SLC18A3ACHEBCHE | |
| SCHEMBL5157349 | 0.85 | FUCA1 (0.66) | ALDH1A1FUCA1SLC18A3ACHEBCHE | |
| SCHEMBL30014513 | 0.85 | FUCA1 (0.71) | ALDH1A1FUCA1SLC18A3SIGMAR1GBA1 | |
| SCHEMBL20484873 | 0.84 | HTR2A (0.48) | ALDH1A1SLC18A3SIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL20484874 | 0.84 | HTR2A (0.48) | ALDH1A1SLC18A3SIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL20485039 | 0.84 | HTR2A (0.48) | ALDH1A1SLC18A3SIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL4436419 | 0.83 | ACHE (0.58) | ACHESIGMAR1 | |
| SCHEMBL14211659 | 0.81 | GBA1 (0.52) | ALDH1A1FUCA1ACHEBCHEBACE1 | |
| SCHEMBL29927577 | 0.81 | GBA1 (0.52) | ALDH1A1FUCA1ACHEBCHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334677-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022076-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-02-25 | — | — | WO | disclosed |