Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19640908 | 0.87 | AKR1C3 (0.55) | AKR1C3KMT2APSEN1PSEN2APH1B | |
| SCHEMBL21913514 | 0.84 | KMT2A (0.47) | AKR1C3KMT2ATDP1HTR6PSEN1 | |
| SCHEMBL19640858 | 0.82 | AKR1C3 (0.49) | AKR1C3KMT2AHTR6PSEN1PSEN2 | |
| SCHEMBL29500394 | 0.80 | AKR1C3 (0.53) | AKR1C3KMT2AHTR6 | |
| SCHEMBL19013676 | 0.80 | AKR1C3 (0.53) | AKR1C3KMT2AHTR6 | |
| Hydrochloric Acid SCHEMBL19640861 | 0.79 | AKR1C3 (0.52) | AKR1C3KMT2AHTR6 | |
| SCHEMBL19640817 | 0.79 | AKR1C3 (0.49) | AKR1C3KMT2AHTR6PSEN1PSEN2 | |
| SCHEMBL19640887 | 0.79 | PSEN1 (0.57) | AKR1C3KMT2APSEN1PSEN2APH1B | |
| SCHEMBL18422148 | 0.78 | CHRNB2 (0.44) | AKR1C3KMT2ATDP1HTR6CHRNB2 | |
| Hydrochloric Acid SCHEMBL19640871 | 0.78 | AKR1C3 (0.48) | AKR1C3KMT2AHTR6PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464288-B1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL)METHANONES | Bayer Pharma AG (DE) | 2020-12-23 | — | — | EP | disclosed |
| EP-3464288-B1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL)METHANONES | Bayer Pharma AG (DE) | 2020-12-23 | — | — | EP | disclosed |
| US-10167293-B2 | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-01-01 | — | — | US | disclosed |
| US-10167293-B2 | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-01-01 | — | — | US | disclosed |
| US-20170342082-A1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL)METHANONES | Bayer Pharma AG (DE) | 2017-11-30 | — | — | US | disclosed |
| US-20170342082-A1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL)METHANONES | Bayer Pharma AG (DE) | 2017-11-30 | — | — | US | disclosed |
| WO-2017202817-A1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL] (1H-1,2,3-TRIAZOL-4-YL)METHANONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342082-A1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL)METHANONES | PKD1, PKD2, PDK3 | AKR1C3 45/4885KMT2A 1334/4885TDP1 344/4885 |
| US-10167293-B2 | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones | PKD1, PKD2, PDK3 | AKR1C3 45/4885KMT2A 1334/4885TDP1 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.