SCHEMBL19643102

SCHEMBL19643102

O=C(C=Cc1ccccc1F)Oc1cccc2cccc(OC(=O)c3ccco3)c12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTSR1 P30989 2/20 0.58
KMT2A Q03164 10/20 0.51
HSD17B10 Q99714 3/20 0.51
POLB P06746 4/20 0.46
KDM4E B2RXH2 2/20 0.46
MAPT P10636 5/20 0.45
LMNA P02545 4/20 0.45
TDP1 Q9NUW8 1/20 0.45
ALDH1A1 P00352 6/20 0.43
RAB9A P51151 3/20 0.43
MEN1 O00255 3/20 0.43
NPC1 O15118 2/20 0.43
HPGD P15428 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
TSHR P16473 2/20 0.41
ALPL P05186 1/20 0.40
ALPI P09923 1/20 0.40
ALPG P10696 1/20 0.40
HTT P42858 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19643101 1.00 NTSR1 (0.58) NTSR1KMT2AHSD17B10POLBKDM4E
SCHEMBL29563649 0.87 KDM4E (0.48) NTSR1KMT2AKDM4EMAPTLMNA
SCHEMBL19656164 0.87 KDM4E (0.48) NTSR1KMT2AKDM4EMAPTLMNA
SCHEMBL19656152 0.84 KMT2A (0.50) KMT2AHSD17B10POLBKDM4EMAPT
SCHEMBL19642828 0.84 MAPT (0.47) NTSR1KMT2AHSD17B10KDM4EMAPT
SCHEMBL19642829 0.84 MAPT (0.47) NTSR1KMT2AHSD17B10KDM4EMAPT
SCHEMBL19642905 0.80 KMT2A (0.59) NTSR1KMT2AHSD17B10POLBKDM4E
SCHEMBL19084339 0.79 KMT2A (0.71) KMT2AHSD17B10POLBKDM4EMAPT
SCHEMBL28706756 0.78 KDM4E (0.38) NTSR1KMT2AHSD17B10POLBKDM4E
SCHEMBL19642825 0.75 KMT2A (0.58) KMT2AHSD17B10POLBKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200223958-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. GRACE & CO.-CONN. (US) 2020-07-16 US claimed
US-20190270831-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W. R. GRACE & CO. - CONN. 2019-09-05 US claimed
EP-3464391-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. Grace & Co.-Conn. (US) 2019-04-10 EP claimed
WO-2017204811-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. GRACE & CO. -CONN. (US) 2017-11-30 WO claimed
EP-3464391-B1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS BRASKEM AMERICA INC (US) 2024-01-03 EP disclosed
US-11370854-B2 Non-phthalate donor for polyolefin catalysts BRASKEM AMERICA, INC. (US) 2022-06-28 US disclosed
US-11291981-B2 Boron-based electron donors for Ziegler-Natta catalyst systems BRASKEM AMERICA, INC. (US) 2022-04-05 US disclosed
US-20200223958-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. GRACE & CO.-CONN. (US) 2020-07-16 US disclosed
US-10662267-B2 Non-phthalate donor for polyolefin catalysts W.R. GRACE & CO. -CONN. (US) 2020-05-26 US disclosed
US-20190270831-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W. R. GRACE & CO. - CONN. 2019-09-05 US disclosed
EP-3464391-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. Grace & Co.-Conn. (US) 2019-04-10 EP disclosed
US-20190046965-A1 BORON-BASED ELECTRON DONORS FOR ZIEGLER-NATTA CATALYST SYSTEMS BRASKEM AMERICA, INC. 2019-02-14 US disclosed
WO-2017204811-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. GRACE & CO. -CONN. (US) 2017-11-30 WO disclosed