SCHEMBL19656152

SCHEMBL19656152

O=C(/C=C/c1ccc(F)cc1)Oc1cccc2cccc(OC(=O)c3ccco3)c12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.50
HSD17B10 Q99714 2/20 0.50
POLB P06746 5/20 0.47
KDM4E B2RXH2 1/20 0.47
LMNA P02545 5/20 0.47
MAPT P10636 5/20 0.47
TDP1 Q9NUW8 1/20 0.47
ALDH1A1 P00352 3/20 0.45
MEN1 O00255 3/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
HTT P42858 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.44
ATM Q13315 1/20 0.44
MAOB P27338 1/20 0.43
HPGD P15428 1/20 0.42
PSMD14 O00487 1/20 0.41
CRHBP P24387 1/20 0.41
RAB9A P51151 1/20 0.41
CRHR2 Q13324 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29563914 0.87 KMT2A (0.52) KMT2APOLBKDM4ELMNAMAPT
SCHEMBL19656162 0.87 KMT2A (0.52) KMT2APOLBKDM4ELMNAMAPT
SCHEMBL19643101 0.84 NTSR1 (0.58) KMT2AHSD17B10POLBKDM4ELMNA
SCHEMBL19643102 0.84 NTSR1 (0.58) KMT2AHSD17B10POLBKDM4ELMNA
SCHEMBL21314854 0.83 ATM (0.43) KMT2APOLBKDM4ELMNAMAPT
SCHEMBL19642886 0.82 KMT2A (0.50) KMT2AKDM4ELMNAMAPTALDH1A1
SCHEMBL19642885 0.82 KMT2A (0.50) KMT2AKDM4ELMNAMAPTALDH1A1
SCHEMBL30712745 0.82 KMT2A (0.50) KMT2AKDM4ELMNAMAPTALDH1A1
SCHEMBL19642825 0.82 KMT2A (0.58) KMT2AHSD17B10POLBKDM4EMAPT
SCHEMBL19084339 0.81 KMT2A (0.71) KMT2AHSD17B10POLBKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11370854-B2 Non-phthalate donor for polyolefin catalysts BRASKEM AMERICA, INC. (US) 2022-06-28 US disclosed
US-20200223958-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. GRACE & CO.-CONN. (US) 2020-07-16 US disclosed
EP-3668643-A1 BORON-BASED ELECTRON DONORS FOR ZIEGLER-NATTA CATALYST SYSTEMS Braskem America, Inc. (US) 2020-06-24 EP disclosed
US-10662267-B2 Non-phthalate donor for polyolefin catalysts W.R. GRACE & CO. -CONN. (US) 2020-05-26 US disclosed
US-20190270831-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W. R. GRACE & CO. - CONN. 2019-09-05 US disclosed
WO-2019036376-A1 BORON-BASED ELECTRON DONORS FOR ZIEGLER-NATTA CATALYST SYSTEMS BRASKEM AMERICA, INC. (US) 2019-02-21 WO disclosed
WO-2017204811-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. GRACE & CO. -CONN. (US) 2017-11-30 WO disclosed