Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | METAP2 | P50579 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.32 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.32 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363622 | 0.91 | KDM4E (0.33) | KDM4EALDH1A1HPGDUSP2CYP2C19 | |
| SCHEMBL27493427 | 0.87 | KDM4E (0.33) | KDM4EALDH1A1HPGDUSP2CYP2C19 | |
| SCHEMBL3819062 | 0.77 | CACNA1H (0.32) | CACNA1HCYP1A2METAP2ABCG2 | |
| SCHEMBL5243865 | 0.74 | METAP2 (0.35) | KDM4ECYP2C19CES2CACNA1BCACNA1H | |
| SCHEMBL3961551 | 0.73 | CACNA1H (0.47) | CACNA1BCACNA1HCACNA1CEGLN1CACNA1G | |
| SCHEMBL14468042 | 0.73 | METAP2 (0.38) | KDM4EHSD17B10CACNA1BCACNA1HCACNA1C | |
| SCHEMBL31023736 | 0.71 | CBFB (0.43) | KDM4EALDH1A1CACNA1BCACNA1HCACNA1C | |
| SCHEMBL3394106 | 0.71 | RIPK1 (0.43) | KDM4ECACNA1BCACNA1HCACNA1CCYP1A2 | |
| SCHEMBL44289 | 0.70 | MAPT (0.33) | KDM4EHPGDUSP2HSD17B10METAP2 | |
| SCHEMBL14445623 | 0.68 | TRPV1 (0.33) | KDM4EALDH1A1CACNA1BCACNA1HCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3463367-A1 | METHOD OF TREATING CANCER BY TARGETING MYELOID-DERIVED SUPPRESSOR CELLS | Purdue Research Foundation (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017205661-A1 | METHOD OF TREATING CANCER BY TARGETING MYELOID-DERIVED SUPPRESSOR CELLS | PURDUE RESEARCH FOUNDATION (US) | 2017-11-30 | — | — | WO | disclosed |