Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27839782 | 0.75 | BIRC5 (0.54) | PDE4BPDE4DPKMCDC7CDK2 | |
| SCHEMBL31070284 | 0.75 | HPGD (0.52) | PDE4BPDE4DPKMCDC7CDK2 | |
| SCHEMBL28545337 | 0.75 | HPGD (0.52) | PDE4BPDE4DPKMCDC7CDK2 | |
| SCHEMBL31049775 | 0.73 | RAPGEF4 (0.44) | RAPGEF4PKMCDC7CDK2SLC22A12 | |
| SCHEMBL30424543 | 0.73 | RAPGEF4 (0.56) | RAPGEF4CDC7CDK2SLC22A12ENPP3 | |
| SCHEMBL10094619 | 0.72 | CDC7 (0.50) | RAPGEF4CDC7CDK2SLC22A12ENPP3 | |
| SCHEMBL4801964 | 0.71 | CDC7 (0.41) | RAPGEF4CDC7CDK2SLC22A12JAK2 | |
| SCHEMBL2295440 | 0.71 | CDC7 (0.56) | RAPGEF4PKMCDC7CDK2SLC22A12 | |
| SCHEMBL16863761 | 0.71 | RAPGEF4 (0.50) | RAPGEF4PDE4BCDC7CDK2SLC22A12 | |
| SCHEMBL28441844 | 0.70 | SLC22A12 (0.53) | RAPGEF4CDC7CDK2SLC22A12SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3463341-A1 | AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES | The Rockefeller University (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017205296-A1 | AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES | THE ROCKEFELLER UNIVERSITY (US) | 2017-11-30 | — | — | WO | disclosed |