Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | HCK | P08631 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3044688 | 0.84 | AKT1 (0.40) | NOTUMHSP90AA1HSP90AB1HTR6BUB1 | |
| SCHEMBL29992652 | 0.84 | AKT1 (0.40) | NOTUMHSP90AA1HSP90AB1HTR6BUB1 | |
| SCHEMBL12422261 | 0.79 | NOTUM (0.47) | NOTUMHSP90AA1HSP90AB1HTR6BUB1 | |
| SCHEMBL19645303 | 0.79 | NOTUM (0.47) | NOTUMHSP90AA1HSP90AB1HTR6BUB1 | |
| SCHEMBL14722904 | 0.78 | NOTUM (0.43) | NOTUMHSP90AA1HSP90AB1HTR6BUB1 | |
| SCHEMBL29631795 | 0.76 | L3MBTL1 (0.44) | NOTUMHSP90AA1HSP90AB1HTR6BUB1 | |
| SCHEMBL18989920 | 0.76 | NOTUM (0.43) | NOTUMHSP90AA1HSP90AB1HTR6BUB1 | |
| SCHEMBL18990682 | 0.76 | L3MBTL1 (0.44) | NOTUMHSP90AA1HSP90AB1HTR6BUB1 | |
| SCHEMBL29631950 | 0.76 | NOTUM (0.43) | NOTUMHSP90AA1HSP90AB1HTR6BUB1 | |
| SCHEMBL1550722 | 0.76 | GABRG2 (0.37) | GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009436-B1 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE LLC (US) | 2019-06-05 | — | — | EP | disclosed |
| US-9828378-B2 | Kinase inhibitors and methods of use | INTELLIKINE LLC (US) | 2017-11-28 | — | — | US | disclosed |