Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20307141 | 0.82 | MPL (0.39) | MPLKDM2BPHF8SLC6A3SLC6A2 | |
| SCHEMBL30580173 | 0.76 | MPL (0.45) | MPLKDM2BPHF8SLC6A3SLC6A2 | |
| SCHEMBL4550818 | 0.76 | MPL (0.45) | MPLKDM2BPHF8SLC6A3SLC6A2 | |
| SCHEMBL28952591 | 0.75 | MPL (0.41) | MPLKDM2BPHF8SLC6A3SLC6A2 | |
| SCHEMBL29875817 | 0.75 | MPL (0.41) | MPLKDM2BPHF8SLC6A3SLC6A2 | |
| SCHEMBL2716488 | 0.75 | MPL (0.41) | MPLKDM2BPHF8SLC6A3SLC6A2 | |
| SCHEMBL17053066 | 0.75 | GABRA1 (0.42) | MPLKDM2BPHF8SLC6A3SLC6A2 | |
| SCHEMBL2713811 | 0.75 | MPL (0.41) | MPLKDM2BPHF8SLC6A3SLC6A2 | |
| Hydrochloric Acid SCHEMBL2715685 | 0.75 | MPL (0.44) | MPLKDM2BPHF8SLC6A3SLC6A2 | |
| SCHEMBL22792332 | 0.74 | ALOX5 (0.48) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828396-B2 | Alkyne compounds for treatment of complement mediated disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2017-11-28 | — | — | US | disclosed |