Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283735 | 0.85 | SIGMAR1 (0.81) | SIGMAR1GAAMAPTATMTAAR1 | |
| SCHEMBL9473053 | 0.84 | SIGMAR1 (0.65) | SIGMAR1GAAMAPTATMTAAR1 | |
| Hydrochloric Acid SCHEMBL5028920 | 0.82 | SIGMAR1 (0.77) | SIGMAR1GAAMAPTATMTAAR1 | |
| SCHEMBL13937400 | 0.82 | SIGMAR1 (0.77) | SIGMAR1GAAMAPTATMTAAR1 | |
| SCHEMBL8140699 | 0.82 | SIGMAR1 (0.77) | SIGMAR1GAAMAPTATMTAAR1 | |
| Hydrochloric Acid SCHEMBL6898901 | 0.82 | SIGMAR1 (0.63) | SIGMAR1GAAMAPTATMTAAR1 | |
| SCHEMBL8608190 | 0.80 | SIGMAR1 (0.67) | SIGMAR1GAAMAPTATMTAAR1 | |
| SCHEMBL10453660 | 0.78 | SIGMAR1 (0.91) | SIGMAR1SLC6A2ADRA1AKCNH2 | |
| SCHEMBL27228 | 0.78 | GAA (0.95) | SIGMAR1GAAMAPTALDH1A1MAOA | |
| SCHEMBL9768701 | 0.78 | SIGMAR1 (0.86) | SIGMAR1GAAMAPTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2018-04-18 | — | — | EP | disclosed |
| EP-2780039-B1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2017-11-29 | — | — | EP | disclosed |