Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19647389 | 1.00 | GRM7 (0.41) | GRM7ACEMAPTGAAXIAP | |
| SCHEMBL16015557 | 0.86 | MTNR1B (0.39) | GRM7ACEXIAPMTNR1BMTNR1A | |
| SCHEMBL19647090 | 0.83 | GRM7 (0.39) | GRM7ACEMAPTGAAXIAP | |
| SCHEMBL11733442 | 0.83 | PPARG (0.45) | ACEMTNR1BMEN1TSHRKMT2A | |
| SCHEMBL19647050 | 0.81 | MTNR1A (0.41) | ACEXIAPMTNR1BMAPK1MTNR1A | |
| SCHEMBL14957322 | 0.79 | GRM2 (0.40) | — | |
| SCHEMBL19647376 | 0.78 | DPP8 (0.41) | GRM7ACEMTNR1BMAPK1MTNR1A | |
| SCHEMBL19647051 | 0.76 | MTNR1B (0.38) | GRM7ACEXIAPMTNR1BMTNR1A | |
| SCHEMBL23615429 | 0.76 | MTNR1B (0.41) | GRM7MTNR1BMAPK1MTNR1AMEN1 | |
| SCHEMBL14956738 | 0.76 | MTNR1B (0.41) | GRM7MTNR1BMAPK1MTNR1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2017-11-29 | — | — | EP | disclosed |