Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA4 | P22748 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14005135 | 0.87 | MEN1 (0.41) | CA2CA12CA1CA4CA9 | |
| SCHEMBL7547013 | 0.87 | MEN1 (0.47) | CA2CA12CA1CA4CA9 | |
| SCHEMBL24592016 | 0.85 | CA2 (0.47) | CA2CA12CA1CA4CA9 | |
| SCHEMBL932617 | 0.84 | SMN1; SMN2 (0.40) | CA2CA12CA1CA4CA9 | |
| SCHEMBL15669304 | 0.84 | SMN1; SMN2 (0.40) | CA2CA12CA1CA4CA9 | |
| SCHEMBL29603294 | 0.84 | SMN1; SMN2 (0.40) | CA2CA12CA1CA4CA9 | |
| SCHEMBL3710469 | 0.84 | SMN1; SMN2 (0.40) | CA2CA12CA1CA4CA9 | |
| SCHEMBL15697632 | 0.84 | SMN1; SMN2 (0.40) | CA2CA12CA1CA4CA9 | |
| SCHEMBL16644687 | 0.84 | SMN1; SMN2 (0.40) | CA2CA12CA1CA4CA9 | |
| SCHEMBL16054966 | 0.82 | CA2 (0.38) | CA2CA12CA1CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2017-11-29 | — | — | EP | disclosed |