Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14968650 | 0.84 | NOTUM (0.36) | NPSR1MMP1HDAC4HTR2AHDAC9 | |
| SCHEMBL14968487 | 0.83 | L3MBTL1 (0.41) | MMP1HDAC4HDAC9BRD4 | |
| SCHEMBL16116728 | 0.71 | HDAC9 (0.44) | HDAC9 | |
| SCHEMBL22341280 | 0.70 | THRB (0.36) | MMP1HDAC9 | |
| SCHEMBL26150401 | 0.70 | KDM1A (0.40) | HDAC9 | |
| SCHEMBL19647091 | 0.70 | CXCR5 (0.37) | MMP1 | |
| SCHEMBL15894653 | 0.68 | CYP1A2 (0.39) | NPSR1HTR2A | |
| SCHEMBL27045431 | 0.68 | TACR1 (0.54) | MMP1HDAC9 | |
| SCHEMBL27579439 | 0.68 | KDM1A (0.45) | — | |
| SCHEMBL27502313 | 0.67 | MEN1 (0.43) | MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2017-11-29 | — | — | EP | disclosed |