Sugi Predict

Sugi Predict / Compounds / SCHEMBL19647639

SCHEMBL19647639

SCHEMBL19647639

Nc1nc2c(c(COCc3ccccc3[N+](=O)[O-])cn2[C@H]2C[C@@H](O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]1

nearest known ligand 0.48

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.47
▸ P2RY2 P41231 3/20 0.47
▸ P2RY4 P51582 3/20 0.47
▸ P2RY6 Q15077 3/20 0.47
▸ TYMS P04818 4/20 0.43
▸ DTYMK P23919 2/20 0.40
▸ DUT P33316 1/20 0.39
▸ FUT5 Q11128 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13573869 1.00 POLB (0.47) POLBP2RY2P2RY4P2RY6TYMS
SCHEMBL14951029 1.00 POLB (0.47) POLBP2RY2P2RY4P2RY6TYMS
SCHEMBL19647644 0.93 POLB (0.45) POLBP2RY2P2RY4P2RY6TYMS
SCHEMBL10179013 0.93 TYMS (0.43) POLBP2RY2P2RY4P2RY6TYMS
SCHEMBL16728016 0.88 P2RY2 (0.43) POLBP2RY2P2RY4P2RY6TYMS
SCHEMBL16728007 0.88 P2RY2 (0.43) POLBP2RY2P2RY4P2RY6TYMS
SCHEMBL16728024 0.88 P2RY2 (0.43) POLBP2RY2P2RY4P2RY6TYMS
SCHEMBL13573809 0.87 TK1 (0.40) POLBTYMS
SCHEMBL10178479 0.87 TK1 (0.40) POLBTYMS
SCHEMBL14951030 0.87 P2RY2 (0.43) POLBP2RY2P2RY4P2RY6TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2307565-B1 REVERSIBLE NUCLEOSIDES AND NUCLEOTIDES TERMINATORS AND THEIR USE IN DNA SEQUENCING LASERGEN INC (US) 2017-11-29 — — EP disclosed