Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1495934 | 0.87 | NR1H4 (0.51) | CA1CA2CA12CA7CA9 | |
| SCHEMBL14175211 | 0.84 | TDP1 (0.52) | CA1CA2CA12CA7CA9 | |
| SCHEMBL25721981 | 0.84 | TDP1 (0.52) | CA1CA2CA12CA7CA9 | |
| SCHEMBL1495870 | 0.83 | MTNR1A (0.44) | CA1CA2CA12CA7CA9 | |
| SCHEMBL2968528 | 0.83 | ALDH1A1 (0.53) | CA1CA2CA12CA7CA9 | |
| SCHEMBL2329286 | 0.83 | NPC1 (0.46) | CA1CA2CA12CA7CA9 | |
| SCHEMBL7143877 | 0.82 | CYP3A4 (0.57) | CA1CA2CA12CA7CA9 | |
| SCHEMBL8733705 | 0.82 | DPP4 (0.48) | CA1CA2CA12CA7CA9 | |
| SCHEMBL10659379 | 0.82 | ALDH1A1 (0.53) | CA1CA2CA12CA7CA9 | |
| SCHEMBL7718888 | 0.81 | CA1 (0.49) | CA1CA2CA12CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229360-B1 | INDOLINONE DERIVATIVES AND PROCESS FOR THEIR MANUFACTURE | BOEHRINGER INGELHEIM INT (DE) | 2020-07-01 | — | — | EP | disclosed |
| EP-2229359-B1 | PROCESS FOR THE MANUFACTURE OF AN INDOLINONE DERIVATIVE | BOEHRINGER INGELHEIM INT (DE) | 2017-11-29 | — | — | EP | disclosed |