Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | LAP3 | P28838 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.37 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29969036 | 0.95 | GRIK1 (0.40) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL7061809 | 0.81 | GPR84 (0.44) | GPR84FFAR1EPHX1LAP3MAPT | |
| SCHEMBL20341607 | 0.74 | GPR84 (0.44) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL17818503 | 0.74 | GPR84 (0.41) | GPR84FFAR1EPHX1MAPTTP53 | |
| SCHEMBL8972391 | 0.73 | EPHX1 (0.39) | GRIK1GRIK2GPR84CA1CA2 | |
| SCHEMBL4553798 | 0.73 | EPHX1 (0.39) | GRIK1GRIK2GPR84CA1CA2 | |
| SCHEMBL3472515 | 0.70 | GPR84 (0.41) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL16326700 | 0.69 | GRIK1 (0.52) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL21929716 | 0.69 | GRIK1 (0.52) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL1814169 | 0.69 | GRIK1 (0.52) | GRIK1GRIK2SLC1A2SLC1A1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968275-B1 | LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2017-11-29 | — | — | EP | disclosed |