Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 10/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.52 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.52 |
| ▸ | ITGAL | P20701 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19648319 | 0.88 | ALDH1A1 (0.54) | GAAJAK2JAK1TYK2HPGD | |
| SCHEMBL28869679 | 0.85 | GAA (0.65) | GAAJAK2JAK1TYK2HPGD | |
| SCHEMBL25051950 | 0.83 | GAA (0.63) | GAAJAK2JAK1TYK2HPGD | |
| SCHEMBL14968580 | 0.83 | GAA (0.63) | GAAJAK2JAK1TYK2HPGD | |
| SCHEMBL18306503 | 0.83 | GAA (0.63) | GAAJAK2JAK1TYK2HPGD | |
| SCHEMBL11100266 | 0.81 | GAA (0.61) | GAAJAK2JAK1TYK2MAPT | |
| SCHEMBL11098006 | 0.81 | GAA (0.61) | GAAJAK2JAK1TYK2HPGD | |
| Hydrochloric Acid SCHEMBL11098010 | 0.80 | GAA (0.59) | GAAJAK2JAK1TYK2MAPT | |
| SCHEMBL11499405 | 0.80 | GAA (0.59) | GAAJAK2JAK1TYK2HPGD | |
| SCHEMBL2876974 | 0.79 | GAA (0.58) | GAAJAK2JAK1TYK2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846804-B1 | TETRAHYDRONAPHTHYRIDINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME (US) | 2017-11-29 | — | — | EP | disclosed |