Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FER | P16591 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925080 | 0.83 | MEN1 (0.40) | MAOAMAOBGSK3BMEN1KMT2A | |
| SCHEMBL16788090 | 0.81 | MEN1 (0.41) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL31314156 | 0.81 | MEN1 (0.41) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL19452869 | 0.81 | MEN1 (0.43) | MAOAMAOBGSK3BMEN1KMT2A | |
| SCHEMBL19650175 | 0.78 | ACVR1 (0.43) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL17816635 | 0.75 | LRRK2 (0.59) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL181764 | 0.75 | LRRK2 (0.59) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL30462618 | 0.75 | LRRK2 (0.59) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL6255304 | 0.69 | LRRK2 (0.58) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL31108400 | 0.69 | LRRK2 (0.46) | LRRK2ACVR1PDGFRAFERLTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2752418-B1 | POLYCYCLIC AROMATIC COMPOUND | UNIV KYOTO (JP) | 2017-11-29 | — | — | EP | disclosed |