Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | MST1R | Q04912 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | YES1 | P07947 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14895823 | 0.84 | MET (0.53) | METFGFR3KDRFGFR2ABL1 | |
| SCHEMBL14894429 | 0.84 | MET (0.65) | METLRRK2FGFR3KDRMST1R | |
| SCHEMBL29924055 | 0.84 | MET (0.65) | METLRRK2FGFR3KDRMST1R | |
| SCHEMBL14906771 | 0.84 | MET (0.50) | METFGFR3KDRFGFR2ABL1 | |
| SCHEMBL3256828 | 0.84 | FGFR3 (0.56) | METFGFR3KDRFGFR2ABL1 | |
| SCHEMBL29870164 | 0.81 | WNT1 (0.55) | METFGFR3KDRFGFR2MAPK1 | |
| SCHEMBL14793376 | 0.81 | PDGFRB (0.62) | METFGFR3KDRFGFR2FGFR1 | |
| SCHEMBL368567 | 0.80 | MET (0.56) | METFGFR3MST1RPDE3BPDE3A | |
| SCHEMBL14915862 | 0.79 | MET (0.58) | METFGFR3KDRMST1RFGFR2 | |
| SCHEMBL28687573 | 0.79 | MET (0.58) | METFGFR3MST1RFGFR2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776397-B1 | QUINOLINES AS FGFR KINASE MODULATORS | ASTEX THERAPEUTICS LTD (GB) | 2017-11-29 | — | — | EP | disclosed |