Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.69 |
| ▸ | RAF1 | P04049 | 1/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.64 |
| ▸ | JAK3 | P52333 | 1/20 | 0.62 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.59 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.59 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.59 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.59 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.59 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12580695 | 1.00 | AURKA (0.69) | AURKARAF1PDPK1JAK3PSEN1 | |
| SCHEMBL8529179 | 0.83 | RAF1 (0.65) | AURKARAF1PDPK1JAK3PSEN1 | |
| SCHEMBL1395364 | 0.81 | RAF1 (0.76) | AURKARAF1PDPK1PSEN1PSEN2 | |
| SCHEMBL1395361 | 0.81 | RAF1 (0.76) | AURKARAF1PDPK1PSEN1PSEN2 | |
| Gw405841X SCHEMBL1395153 | 0.81 | RAF1 (1.00) | AURKARAF1PDPK1PSEN1PSEN2 | |
| Gw405841X SCHEMBL1395154 | 0.81 | RAF1 (1.00) | AURKARAF1PDPK1PSEN1PSEN2 | |
| SCHEMBL14674418 | 0.80 | KDR (0.72) | JAK3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29638292 | 0.80 | KDR (0.72) | JAK3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14674419 | 0.80 | KDR (0.72) | JAK3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4413790 | 0.80 | MEN1 (0.73) | PDPK1JAK3PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509946-B1 | SPIRO INDOLE-CYCLOPROPANE INDOLINONES USEFUL AS AMPK MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-04-16 | — | — | EP | disclosed |
| US-20130102604-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-04-25 | — | — | US | disclosed |
| US-8354443-B2 | Cyclopropane indolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-2509946-A1 | SPIRO INDOLE - CYCLOPROPANE INDOLINONES USEFUL AS AMPK MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011069298-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070039-A1 | SPIRO INDOLE - CYCLOPROPANE INDOLINONES USEFUL AS AMPK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |
| US-20110144106-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144106-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | GPR119, CPT1A, IRS1 | AURKA 4252/4885RAF1 1707/4885PDPK1 171/4885 |
| US-20130102604-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | GPR119, CPT1A, IRS1 | AURKA 4244/4885RAF1 1740/4885PDPK1 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.