Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658764 | 0.86 | MEN1 (0.54) | CCR5MLNRKCNH2PRKAA2MEN1 | |
| SCHEMBL19652127 | 0.86 | MLNR (0.52) | CCR5MLNRKCNH2DRD2HTR2A | |
| SCHEMBL19652131 | 0.85 | KCNH2 (0.52) | KCNH2DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL13478887 | 0.84 | CCR5 (0.57) | CCR5MLNRKCNH2PRKAA2MEN1 | |
| SCHEMBL13588400 | 0.84 | SIGMAR1 (0.62) | KCNH2DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL19652144 | 0.82 | CHRM2 (0.54) | CCR5KCNH2MEN1KMT2ASIGMAR1 | |
| SCHEMBL16569508 | 0.81 | HRH3 (0.54) | MLNRPRKAA2MEN1CYP1A2CYP2C9 | |
| SCHEMBL19652090 | 0.77 | SIGMAR1 (0.54) | CCR5KCNH2DRD2HTR2AHTR2C | |
| SCHEMBL17975502 | 0.76 | HRH3 (0.61) | CCR5MLNRPRKAA2SIGMAR1 | |
| SCHEMBL12384426 | 0.75 | HRH3 (0.52) | MLNRKCNH2PRKAA2MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | CCR5 1178/4885MLNR 4453/4885KCNH2 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.