Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 2/20 | 0.68 |
| ▸ | PTK2 | Q05397 | 14/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.68 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.68 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.68 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.68 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.60 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.58 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.58 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | JAK3 | P52333 | 2/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.56 |
| ▸ | CHUK | O15111 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754823 | 0.96 | PTK2 (0.73) | ULK1PTK2FGFR1FGFR3FGFR2 | |
| SCHEMBL19654194 | 0.92 | ULK1 (0.65) | ULK1PTK2FGFR1FGFR3FGFR2 | |
| SCHEMBL19654219 | 0.88 | ULK1 (0.63) | ULK1PTK2FGFR1FGFR3FGFR2 | |
| SCHEMBL19654234 | 0.87 | ULK1 (0.62) | ULK1PTK2FGFR1FGFR3FGFR2 | |
| SCHEMBL19654228 | 0.87 | ULK1 (0.91) | ULK1PTK2FGFR1FGFR3FGFR2 | |
| SCHEMBL17547467 | 0.86 | PTK2 (0.75) | ULK1PTK2FGFR1FGFR3FGFR2 | |
| SCHEMBL23754871 | 0.86 | PTK2 (0.72) | ULK1PTK2FGFR1FGFR3FGFR2 | |
| SCHEMBL17544689 | 0.86 | PTK2 (0.72) | ULK1PTK2FGFR1FGFR3FGFR2 | |
| SCHEMBL30086170 | 0.86 | PTK2 (0.72) | ULK1PTK2FGFR1FGFR3FGFR2 | |
| SCHEMBL23754829 | 0.86 | PTK2 (0.72) | ULK1PTK2FGFR1FGFR3FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170342088-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342088-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | ULK1, ULK2, ULK3 | ULK1 1/4885PTK2 884/4885FGFR1 1715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.