Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 4/20 | 0.59 |
| ▸ | MERTK | Q12866 | 3/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.59 |
| ▸ | CCNK | O75909 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CCND3 | P30281 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 6/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.50 |
| ▸ | ULK1 | O75385 | 6/20 | 0.49 |
| ▸ | ULK2 | Q8IYT8 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29695649 | 0.88 | EGFR (0.61) | TYRO3MERTKFLT3GAS6CDK2 | |
| SCHEMBL19654497 | 0.86 | AURKA (0.59) | SYKEGFRJAK3ITKULK1 | |
| SCHEMBL19654389 | 0.85 | ULK1 (0.47) | TYRO3MERTKFLT3GAS6SYK | |
| SCHEMBL19654416 | 0.84 | ULK1 (0.68) | TYRO3MERTKFLT3GAS6SYK | |
| SCHEMBL29695680 | 0.83 | EGFR (0.65) | TYRO3MERTKSYKEGFRJAK3 | |
| SCHEMBL29695669 | 0.83 | EGFR (0.65) | TYRO3SYKEGFRJAK3ITK | |
| SCHEMBL19654431 | 0.82 | ULK1 (0.53) | TYRO3MERTKFLT3GAS6SYK | |
| SCHEMBL29695672 | 0.82 | EGFR (0.64) | TYRO3MERTKSYKEGFRJAK3 | |
| SCHEMBL17545133 | 0.81 | ULK1 (0.74) | ULK1ULK2 | |
| SCHEMBL19654464 | 0.81 | ULK1 (0.72) | TYRO3MERTKFLT3GAS6SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170342088-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342088-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | ULK1, ULK2, ULK3 | TYRO3 2012/4885MERTK 196/4885FLT3 1303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.