Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 4/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19641997 | 0.89 | CACNA1B (0.39) | CACNA1BANO1POLBMAPTMEN1 | |
| SCHEMBL29727633 | 0.86 | JAK2 (0.38) | CACNA1BPOLBMAPTMEN1KMT2A | |
| SCHEMBL19641914 | 0.86 | POLB (0.36) | CACNA1BPOLBMAPTMEN1KMT2A | |
| SCHEMBL19641931 | 0.86 | JAK2 (0.38) | CACNA1BPOLBMAPTMEN1KMT2A | |
| SCHEMBL19641895 | 0.85 | LMNA (0.39) | POLBMAPTNPC1MEN1KMT2A | |
| SCHEMBL19641917 | 0.83 | CNR1 (0.44) | ANO1RIPK1LMNA | |
| SCHEMBL19641910 | 0.83 | CNR2 (0.37) | ANO1POLBMAPTRIPK1LMNA | |
| SCHEMBL19656290 | 0.83 | CACNA1B (0.46) | CACNA1BANO1POLBMAPTMEN1 | |
| SCHEMBL19641953 | 0.82 | SMN1; SMN2 (0.40) | MAPTNPC1MEN1KMT2AGAA | |
| SCHEMBL19641920 | 0.82 | KMO (0.36) | CACNA1BRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464246-B1 | PYRAZOL COMPOUNDS AS EAAT3 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2020-07-08 | — | — | EP | disclosed |
| WO-2017202896-A1 | PYRAZOL COMPOUNDS AS EAAT3 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-11-30 | — | — | WO | disclosed |