Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 6/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16690038 | 0.97 | ALOX15 (0.72) | ALOX15HPGDL3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL24365820 | 0.88 | ALDH1A1 (0.59) | ALOX15HPGDL3MBTL1ALDH1A1POLB | |
| SCHEMBL1912032 | 0.88 | POLB (0.61) | ALOX15HPGDL3MBTL1ALDH1A1POLB | |
| SCHEMBL14345429 | 0.87 | KMT2A (0.73) | ALOX15HPGDL3MBTL1ALDH1A1POLB | |
| SCHEMBL17689118 | 0.84 | HPGD (0.66) | ALOX15HPGDL3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL17689086 | 0.83 | HPGD (0.64) | HPGDL3MBTL1HSD17B10ALDH1A1POLB | |
| SCHEMBL29944081 | 0.83 | HPGD (0.76) | HPGDL3MBTL1HSD17B10ALDH1A1POLB | |
| SCHEMBL17758483 | 0.82 | HPGD (0.67) | HPGDL3MBTL1HSD17B10ALDH1A1POLB | |
| SCHEMBL12569382 | 0.82 | HPGD (0.71) | HPGDALDH1A1POLBSMN1; SMN2GAA | |
| SCHEMBL19651816 | 0.81 | HPGD (0.61) | HPGDL3MBTL1HSD17B10ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-B1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH INC (US) | 2022-04-27 | — | — | EP | disclosed |
| US-20170340605-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340605-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRPF3 | ALOX15 4124/4885HPGD 1603/4885L3MBTL1 2782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.