SCHEMBL19657640

SCHEMBL19657640

C=C(C)c1cc(CCCCc2cc(-c3cnn(C)c3)c(C(F)F)cc2C)cc(N(C)C=O)c1N(C)C

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 13/20 0.34
BRD4 O60885 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19657767 0.78 CREBBP (0.35) CREBBPBRD4
SCHEMBL21255156 0.72 CREBBP (0.41) CREBBPBRD4
SCHEMBL19657663 0.72 CREBBP (0.43) CREBBPBRD4
SCHEMBL19657918 0.68 CREBBP (0.42) CREBBPBRD4
SCHEMBL19657348 0.68 CREBBP (0.32) CREBBP
SCHEMBL21254945 0.67 CREBBP (0.40) CREBBPBRD4
SCHEMBL19657345 0.67 CREBBP (0.32) CREBBP
SCHEMBL24258507 0.66 CREBBP (0.60) CREBBPBRD4
SCHEMBL24258490 0.66 CREBBP (0.43) CREBBPBRD4
SCHEMBL19657927 0.65 CREBBP (0.36) CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017205536-A2 THERAPEUTIC COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2017-11-30 WO disclosed