Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 19/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21255156 | 0.95 | CREBBP (0.41) | CREBBPBRD4EP300KCNH2 | |
| SCHEMBL19657927 | 0.92 | CREBBP (0.36) | CREBBPKCNH2 | |
| SCHEMBL21254945 | 0.80 | CREBBP (0.40) | CREBBPBRD4EP300 | |
| SCHEMBL17794959 | 0.78 | CREBBP (0.47) | CREBBPBRD4EP300KCNH2 | |
| SCHEMBL19657389 | 0.75 | CREBBP (0.40) | CREBBPBRD4EP300 | |
| SCHEMBL17794669 | 0.71 | LRRK2 (0.48) | CREBBPBRD4EP300KCNH2 | |
| SCHEMBL19369018 | 0.70 | KCNH2 (0.45) | CREBBPBRD4EP300KCNH2 | |
| SCHEMBL17795290 | 0.70 | USP30 (0.39) | — | |
| SCHEMBL19660413 | 0.70 | CREBBP (0.47) | CREBBPBRD4EP300 | |
| SCHEMBL19538922 | 0.69 | CREBBP (0.46) | CREBBPBRD4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3224258-B1 | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH INC (US) | 2019-08-14 | — | — | EP | disclosed |
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |