Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAF1 | P21675 | 3/20 | 0.48 |
| ▸ | CECR2 | Q9BXF3 | 3/20 | 0.48 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | SORD | Q00796 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GBA1 | P04062 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658784 | 0.86 | TAF1 (0.51) | TAF1CECR2BRD9MAP4K4GAA | |
| SCHEMBL19652211 | 0.86 | TAF1 (0.47) | TAF1CECR2BRD9SORDTDP1 | |
| SCHEMBL19658491 | 0.86 | CHRM3 (0.43) | TAF1CECR2BRD9MAP4K4TDP1 | |
| SCHEMBL785081 | 0.78 | SIGMAR1 (0.47) | TAF1CECR2BRD9TDP1GBA1 | |
| SCHEMBL28805790 | 0.76 | GBA1 (0.52) | TAF1CECR2BRD9TDP1GBA1 | |
| SCHEMBL10169430 | 0.76 | TDP1 (0.67) | SORDTDP1GBA1LMNASMN1; SMN2 | |
| SCHEMBL16222432 | 0.75 | SMN1; SMN2 (0.60) | SORDTDP1GAALMNASMN1; SMN2 | |
| SCHEMBL793103 | 0.74 | HPGD (0.53) | TDP1GAALMNASMN1; SMN2HPGD | |
| SCHEMBL12452908 | 0.73 | HRH3 (0.50) | SORDTDP1GAALMNASMN1; SMN2 | |
| SCHEMBL19652228 | 0.73 | CHRM3 (0.41) | TAF1CECR2BRD9TDP1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | TAF1 439/4885CECR2 184/4885BRD9 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.