Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAF1 | P21675 | 4/20 | 0.51 |
| ▸ | CECR2 | Q9BXF3 | 4/20 | 0.51 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19652226 | 0.87 | TAF1 (0.51) | TAF1CECR2BRD9HRH4CXCR4 | |
| SCHEMBL19658409 | 0.86 | TAF1 (0.48) | TAF1CECR2BRD9MAP4K4KDM4E | |
| SCHEMBL19658491 | 0.80 | CHRM3 (0.43) | TAF1CECR2BRD9MAP4K4KDM4E | |
| SCHEMBL19652211 | 0.72 | TAF1 (0.47) | TAF1CECR2BRD9KDM4EALDH1A1 | |
| SCHEMBL19658594 | 0.69 | KDM4E (0.58) | KDM4EALDH1A1GAAGPR119 | |
| SCHEMBL28805790 | 0.68 | GBA1 (0.52) | TAF1CECR2BRD9HRH4KDM4E | |
| SCHEMBL19658591 | 0.68 | GPR119 (0.44) | MAP4K4KDM4EHPGDHSD17B10GPR119 | |
| SCHEMBL19658736 | 0.68 | GPR119 (0.52) | TAF1CECR2BRD9MAP4K4GPR119 | |
| SCHEMBL19658466 | 0.68 | RIPK1 (0.46) | MAP4K4OPRD1 | |
| SCHEMBL19652228 | 0.68 | CHRM3 (0.41) | TAF1CECR2BRD9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | TAF1 439/4885CECR2 184/4885BRD9 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.