Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.53 |
| ▸ | SKP1 | P63208 | 1/20 | 0.53 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.53 |
| ▸ | SMO | Q99835 | 1/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | SORD | Q00796 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
| ▸ | STK3 | Q13188 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920367 | 0.87 | GPR119 (0.51) | CKS1BSKP1SKP2GPR119CCNC | |
| SCHEMBL24015528 | 0.86 | CHRM4 (0.53) | CKS1BSKP1SKP2GPR119CCNC | |
| SCHEMBL19652122 | 0.85 | GPR119 (0.50) | GPR119CCNCCDK8CNR1RIPK1 | |
| SCHEMBL2273767 | 0.82 | GPR119 (0.65) | CKS1BSKP1SKP2GPR119CCNC | |
| SCHEMBL2301058 | 0.82 | CKS1B (0.60) | CKS1BSKP1SKP2GPR119SMO | |
| SCHEMBL12639924 | 0.81 | GPR119 (0.56) | GPR119RIPK1LSSSORDAKT1 | |
| SCHEMBL803347 | 0.81 | GPR119 (0.49) | GPR119CCNCCDK8RIPK1SORD | |
| Hydrochloric Acid SCHEMBL19639676 | 0.80 | GPR119 (0.48) | GPR119CCNCCDK8RIPK1SORD | |
| Hydrochloric Acid SCHEMBL785329 | 0.80 | GPR119 (0.48) | GPR119CCNCCDK8RIPK1SORD | |
| SCHEMBL7334224 | 0.80 | DRD2 (0.49) | CKS1BSKP1SKP2SMOCCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | CKS1B 239/4885SKP1 2240/4885SKP2 2256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.