Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11914744 | 0.83 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EHSD17B10SCN5A | |
| SCHEMBL19292586 | 0.78 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4EHSD17B10SCN5A | |
| SCHEMBL1189278 | 0.74 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2KDM4EHSD17B10SCN5A | |
| SCHEMBL11918906 | 0.74 | KDM4E (0.56) | ALDH1A1SMN1; SMN2KDM4EHSD17B10SCN5A | |
| SCHEMBL19659055 | 0.73 | SMN1; SMN2 (0.32) | SMN1; SMN2RAB9A | |
| Bromide SCHEMBL1189112 | 0.72 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2KDM4EHSD17B10SCN5A | |
| SCHEMBL18365954 | 0.72 | RBP4 (0.51) | ALDH1A1SMN1; SMN2KDM4EHSD17B10SCN5A | |
| SCHEMBL19292958 | 0.71 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2KDM4EHSD17B10SCN5A | |
| SCHEMBL13687300 | 0.71 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2KDM4EHSD17B10SCN5A | |
| SCHEMBL24654157 | 0.71 | SCN5A (0.41) | ALDH1A1SMN1; SMN2KDM4EHSD17B10SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |