Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377672 | 0.83 | RIPK1 (0.44) | KDM4EKMT2AALDH1A1CSNK1DL3MBTL1 | |
| SCHEMBL18365749 | 0.81 | RIPK1 (0.33) | RIPK1 | |
| SCHEMBL30092748 | 0.74 | KDM4E (0.34) | KDM4EKMT2AALDH1A1CSNK1DL3MBTL1 | |
| SCHEMBL18372237 | 0.72 | RIPK1 (0.42) | KDM4EKMT2AALDH1A1CSNK1DL3MBTL1 | |
| SCHEMBL18377671 | 0.70 | CYP19A1 (0.38) | KDM4EKMT2AALDH1A1CSNK1DL3MBTL1 | |
| SCHEMBL18372493 | 0.69 | CYP19A1 (0.35) | KDM4EKMT2AALDH1A1CSNK1DL3MBTL1 | |
| SCHEMBL29080952 | 0.69 | KDM4E (0.36) | KDM4EKMT2AALDH1A1CSNK1DL3MBTL1 | |
| SCHEMBL18039533 | 0.68 | POLB (0.45) | KDM4EKMT2AALDH1A1HSD17B10TP53 | |
| SCHEMBL16224777 | 0.67 | HDAC4 (0.38) | KDM4EKMT2AL3MBTL1TP53HDAC4 | |
| SCHEMBL16516929 | 0.67 | MEN1 (0.44) | KDM4EKMT2AALDH1A1HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |