Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 4/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18372493 | 0.87 | CYP19A1 (0.35) | KDM4EHSD17B10ELANECYP19A1ALDH1A1 | |
| SCHEMBL18372237 | 0.81 | RIPK1 (0.42) | KDM4EHSD17B10ELANECYP19A1ALDH1A1 | |
| SCHEMBL18377671 | 0.79 | CYP19A1 (0.38) | KDM4EHSD17B10ELANECYP19A1JAK3 | |
| SCHEMBL30092748 | 0.77 | KDM4E (0.34) | KDM4EHSD17B10ELANECYP19A1ALDH1A1 | |
| SCHEMBL18039533 | 0.72 | POLB (0.45) | KDM4EHSD17B10CYP19A1ALDH1A1MEN1 | |
| SCHEMBL16516929 | 0.71 | MEN1 (0.44) | KDM4EHSD17B10CYP19A1ALDH1A1MEN1 | |
| SCHEMBL18377672 | 0.70 | RIPK1 (0.44) | KDM4EHSD17B10ALDH1A1CSNK1DL3MBTL1 | |
| SCHEMBL30236179 | 0.70 | IDO1 (0.35) | KDM4EHSD17B10ELANEALDH1A1MEN1 | |
| SCHEMBL19658994 | 0.69 | KDM4E (0.34) | KDM4EHSD17B10CYP19A1ALDH1A1CSNK1D | |
| SCHEMBL18372534 | 0.69 | RIPK1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |