Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.37 |
| ▸ | GABRP | O00591 | 3/20 | 0.37 |
| ▸ | GABRD | O14764 | 3/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.37 |
| ▸ | GABRE | P78334 | 3/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18945474 | 0.79 | MAPK1 (0.41) | MAPK1LCKGABRA1GABRG2GABRB3 | |
| SCHEMBL882196 | 0.69 | HCAR3 (0.46) | MAPK1LCKGABRA1GABRG2GABRB3 | |
| SCHEMBL68869 | 0.66 | MAPK1 (0.63) | MAPK1LCKGABRA1GABRG2GABRB3 | |
| SCHEMBL24070459 | 0.66 | MAPK1 (0.42) | MAPK1LCKGABRA1GABRG2GABRB3 | |
| SCHEMBL30209743 | 0.66 | MAPK1 (0.42) | MAPK1LCKGABRA1GABRG2GABRB3 | |
| SCHEMBL18825226 | 0.66 | MAPK1 (0.53) | MAPK1LCKGABRA1GABRG2GABRB3 | |
| SCHEMBL23767845 | 0.65 | MAPK1 (0.45) | MAPK1LCKGABRA1GABRG2GABRB3 | |
| SCHEMBL23623861 | 0.65 | ALDH1A1 (0.47) | MAPK1LCKGABRA1GABRG2GABRB3 | |
| SCHEMBL21616761 | 0.65 | MAPK1 (0.45) | MAPK1LCKGABRA1GABRG2GABRB3 | |
| SCHEMBL18725369 | 0.65 | MAPK1 (0.45) | MAPK1LCKGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |