Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658700 | 0.86 | NUDT1 (0.38) | EGLN2PARP1NUDT1JAK1TYK2 | |
| SCHEMBL19659252 | 0.85 | KDM4E (0.37) | EGLN2PARP1NUDT1JAK1GRM2 | |
| SCHEMBL13504386 | 0.80 | NUDT1 (0.62) | EGLN2NUDT1JAK1JAK3 | |
| SCHEMBL2730240 | 0.80 | NUDT1 (0.62) | EGLN2PARP1NUDT1JAK1JAK2 | |
| SCHEMBL23754207 | 0.79 | JAK1 (0.51) | EGLN2NPC1RAB9AJAK1TYK2 | |
| SCHEMBL22439076 | 0.76 | KDM4E (0.43) | PARP1RAB9ANUDT1 | |
| SCHEMBL28485655 | 0.73 | AHR (0.47) | PARP1NUDT1 | |
| SCHEMBL19659614 | 0.72 | KDM4E (0.43) | PARP1 | |
| SCHEMBL13031263 | 0.72 | JAK1 (0.72) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL2145114 | 0.71 | EGLN2 (0.49) | EGLN2JAK1TYK2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |