Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19659562 | 0.83 | PARP1 (0.48) | GRM2SCN9APARP1SCN10A | |
| SCHEMBL12756983 | 0.73 | APOBEC3A (0.49) | TP53 | |
| SCHEMBL12756971 | 0.72 | TP53 (0.39) | TP53NPC1RAB9A | |
| SCHEMBL19260814 | 0.72 | GRM2 (0.52) | GRM2SCN9APARP1NPC1RAB9A | |
| SCHEMBL18372931 | 0.71 | APOBEC3A (0.46) | PARP1 | |
| SCHEMBL28410772 | 0.70 | APOBEC3A (0.45) | PARP1 | |
| SCHEMBL15652101 | 0.69 | NPC1 (0.55) | TP53NPC1RAB9A | |
| SCHEMBL30140611 | 0.69 | NPC1 (0.50) | GRM2TP53NPC1RAB9A | |
| SCHEMBL30587616 | 0.68 | DHODH (0.38) | PARP1 | |
| SCHEMBL17439618 | 0.65 | HTR5A (0.41) | GRM2SCN9ACDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |