Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | PRKCH | P24723 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12426316 | 0.88 | MAOA (0.52) | MAOACHUKPRKD3PRKCGPRKCB | |
| SCHEMBL812489 | 0.81 | CYP1A2 (0.46) | MAOACHUKMAPTLMNANPC1 | |
| SCHEMBL5449879 | 0.79 | AXL (0.50) | MAOACHUKPRKD3PRKCGPRKCB | |
| SCHEMBL13686669 | 0.78 | MAOA (0.47) | MAOACHUKPRKD3PRKCGPRKCB | |
| SCHEMBL5450851 | 0.78 | TNF (0.50) | MAOAMAPTLMNANPC1CYP19A1 | |
| SCHEMBL23762033 | 0.77 | MAOA (0.42) | MAOACHUKPRKD3PRKCGPRKCB | |
| SCHEMBL21237179 | 0.77 | MAOA (0.42) | MAOACHUKPRKD3PRKCGPRKCB | |
| SCHEMBL31483347 | 0.76 | AXL (0.55) | MAOACHUKPRKD3PRKCGPRKCB | |
| SCHEMBL5661372 | 0.76 | IDO1 (0.58) | MAOACHUKPRKD3PRKCGPRKCB | |
| SCHEMBL30863530 | 0.76 | IDO1 (0.58) | MAOACHUKPRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |