Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662822 | 0.98 | KDM4E (0.55) | KDM4EGAAL3MBTL1TDP1HTR3A | |
| SCHEMBL19662780 | 0.88 | HTR3A (0.66) | KDM4EHTR3AKMT2AALDH1A1TSHR | |
| SCHEMBL19662806 | 0.86 | HTR3A (0.43) | KDM4EGAAL3MBTL1TDP1HTR3A | |
| SCHEMBL23761895 | 0.81 | HTR3A (0.45) | KDM4EGAAL3MBTL1TDP1HTR3A | |
| SCHEMBL23762061 | 0.81 | HTR3A (0.45) | KDM4EGAAL3MBTL1TDP1HTR3A | |
| SCHEMBL21237245 | 0.81 | HTR3A (0.46) | KDM4EGAAL3MBTL1TDP1HTR3A | |
| SCHEMBL19662814 | 0.81 | CREBBP (0.44) | KDM4EGAAL3MBTL1TDP1HTR3A | |
| SCHEMBL19662997 | 0.80 | CREBBP (0.47) | KDM4EHTR3ACNR2KMT2ATSHR | |
| SCHEMBL23762011 | 0.80 | CREBBP (0.47) | KDM4EHTR3ACNR2KMT2ATSHR | |
| SCHEMBL19662811 | 0.80 | CREBBP (0.47) | KDM4EGAAL3MBTL1TDP1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |