Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.44 |
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966122 | 1.00 | EGLN1 (0.44) | EGLN1EGLN3EGLN2HIF1ACNR2 | |
| SCHEMBL1967178 | 0.93 | CNR2 (0.42) | EGLN1EGLN3EGLN2HIF1ACNR2 | |
| SCHEMBL1967179 | 0.93 | CNR2 (0.42) | EGLN1EGLN3EGLN2HIF1ACNR2 | |
| SCHEMBL1967838 | 0.90 | P2RX3 (0.39) | EGLN1EGLN3EGLN2HIF1A | |
| SCHEMBL1967836 | 0.90 | P2RX3 (0.39) | EGLN1EGLN3EGLN2HIF1A | |
| SCHEMBL1966718 | 0.89 | EGLN1 (0.50) | EGLN1EGLN3EGLN2HIF1A | |
| SCHEMBL1971041 | 0.87 | EGLN1 (0.53) | EGLN1EGLN3EGLN2HIF1A | |
| SCHEMBL1968648 | 0.84 | EGLN1 (0.47) | EGLN1EGLN3EGLN2 | |
| SCHEMBL1968650 | 0.84 | EGLN1 (0.47) | EGLN1EGLN3EGLN2 | |
| SCHEMBL1968474 | 0.83 | EGLN1 (0.42) | EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102264740-A | Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators | — | 2011-11-30 | — | — | CN | claimed |
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | claimed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | claimed |
| CN-102264740-A | Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators | — | 2011-11-30 | — | — | CN | disclosed |
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | disclosed |